assertion retraction graph subject predicate object datatype annotation 1 0 graph DOID:0081064 rdfs:label BN2 diffuse large B-cell lymphoma @en 1 0 graph DOID:0081064 oio:inSubset obo:doid#DO_cancer_slim _IRI 1 0 graph DOID:0081064 oio:id DOID:0081064 xsd:string 1 0 graph DOID:0081064 oio:hasOBONamespace disease_ontology xsd:string 1 0 graph DOID:0081064 oio:hasExactSynonym BN2 DLBCL xsd:string 1 0 graph DOID:0081064 oio:hasDbXref NCI:C148395 xsd:string 1 0 graph DOID:0081064 rdfs:subClassOf DOID:0050745 _IRI 1 0 graph DOID:0081064 rdf:type owl:Class _IRI 1 0 graph DOID:0081064 IAO:0000115 A diffuse large B-cell lymphoma that is categorized as BN2 with high probability by the LymphGen algorithm. This is based on a combination of genetic features and BN2 DLBCLs often, but do not always, have a translocation involving the BCL6 locus and/or some combination of mutations affecting NOTCH2, TNFAIP3, BCL10 and UBE2A. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting CD70, which can be coding or non-coding. xsd:string "{""oio:hasDbXref"":[{""datatype"":""xsd:string"",""meta"":""owl:Axiom"",""object"":""url:https://pubmed.ncbi.nlm.nih.gov/29641966/""},{""datatype"":""xsd:string"",""meta"":""owl:Axiom"",""object"":""url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459709/""}]}"