disease_tree
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DOID:0081065
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label
- EZB diffuse large B-cell lymphoma @en
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definition
- A diffuse large B-cell lymphoma that is categorized as EZB with high probability by the LymphGen algorithm. This is based on a combination of genetic features and EZB DLBCLs often, but do not always, have hot spot mutations in EZH2 and/or a BCL2 translocation. This class can be further subdivided into two sub-classes EZB-MYC+ and EZB-MYC- using the double hit gene expression signature (DHITsig). This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting IRF8, which can be coding or non-coding.
xsd:string
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oio:hasDbXref
- url:https://pubmed.ncbi.nlm.nih.gov/29641966/ xsd:string
- url:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459709/ xsd:string
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oio:hasDbXref
- A diffuse large B-cell lymphoma that is categorized as EZB with high probability by the LymphGen algorithm. This is based on a combination of genetic features and EZB DLBCLs often, but do not always, have hot spot mutations in EZH2 and/or a BCL2 translocation. This class can be further subdivided into two sub-classes EZB-MYC+ and EZB-MYC- using the double hit gene expression signature (DHITsig). This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting IRF8, which can be coding or non-coding.
xsd:string
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has exact synonym
- EZB DLBCL xsd:string
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has_obo_namespace
- disease_ontology xsd:string
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id
- DOID:0081065 xsd:string
- in_subset
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oio:hasDbXref
- NCI:C148398 xsd:string
- rdf:type
- rdfs:subClassOf